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Comparison of Isoflurane and α-Chloralose in an Anesthetized Swine Model of Acute Pulmonary Embolism Producing Right Ventricular Dysfunction.
Abstract Pulmonary embolism (PE) is a leading cause of sudden cardiac death, and a model is needed for testing potential treatments. In developing a model, we compared the hemodynamic effects of isoflurane and α-chloralose in an acute swine model of PE because the choice of anesthesia will likely affect the cardiovascular responses of an animal to PE. At baseline, swine that received α-chloralose (n = 6) had a lower heart rate and cardiac output and higher SpO2, end-tidal CO2, and mean arterial pressure than did those given isoflurane (n = 9). After PE induction, swine given α-chloralose compared with isofluran...
Source: Comparative Medicine - March 4, 2015 Category: Zoology Authors: Beam DM, Neto-Neves EM, Stubblefield WB, Alves NJ, Tune JD, Kline JA Tags: Comp Med Source Type: research

Five Ways to Fight the Swine Flu
View the Swine Flu video here.   Winter in North America brings with it yearly uninvited guests- flu bugs- multiple strains of illness causing viruses just waiting for new bodies to infect.   The most common recommendation has been to protect yourself with a flu vaccine.  But with virtually all the US flu suddenly resistant to the leading antiviral Tamiflu, health officials are worried about where this could lead.  Here are some key guidelines you MUST know if you want to survive this year’s flu season.   How can you distinguish a cold from the flu? First understand that colds are minor infections of the nose and t...
Source: Dr. Donna, MedicineWoman - January 25, 2009 Category: Medical Scientists Authors: Dr. Donna Tags: breaking news Personal Health public health flu influenza pandemic prevention swine flu tamiflu treatment Source Type: blogs

Cardiac remodeling in a swine model of chronic thrombo-embolic pulmonary hypertension- comparison of right vs. left ventricle.
In conclusion, RV-remodeling in our CTEPH swine model is associated with increased expression of genes involved in inflammation and oxidative stress, suggesting that these processes contribute to RV remodeling and dysfunction in CTEPH and hence represent potential therapeutic targets. This article is protected by copyright. All rights reserved. PMID: 31194256 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - June 12, 2019 Category: Physiology Authors: Stam K, Cai Z, van der Velde N, van Duin R, Lam E, van der Velden J, Hirsch A, Duncker DJ, Merkus D Tags: J Physiol Source Type: research

Impaired pulmonary vasomotor control in exercising swine with multiple comorbidities
In conclusion, common comorbidities directly alter pulmonary vascular control, by enhanced PDE5 and endothelin-mediated vasoconstrictor influences, well before overt left ventricular backward failure or pulmonary hypertension develop.
Source: Basic Research in Cardiology - September 12, 2021 Category: Cardiology Source Type: research

Exercise Facilitates Early Recognition of Cardiac and Vascular Remodeling in Chronic Thrombo-Embolic Pulmonary Hypertension in a Novel CTEPH Swine Model.
In conclusion, embolization in combination with endothelial dysfunction results in CTEPH in swine. Exercise increased RV afterload, exacerbated the V/Q mismatch and unmasked RV dysfunction. PMID: 29167118 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 22, 2017 Category: Physiology Authors: Stam K, van Duin RWB, Uitterdijk A, Cai Z, Duncker DJ, Merkus D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Transition from post-capillary pulmonary hypertension to combined pre- and post-capillary pulmonary hypertension in swine: A key role for endothelin.
This article is protected by copyright. All rights reserved. PMID: 29799120 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - May 25, 2018 Category: Physiology Authors: van Duin RWB, Stam K, Cai Z, Uitterdijk A, Garcia-Alvarez A, Ibanez B, Danser AJ, Reiss IKM, Duncker DJ, Merkus D Tags: J Physiol Source Type: research

Exercise and hypoxia unmask pulmonary vascular disease and right ventricular dysfunction in a 10-12  week old swine model of neonatal oxidative injury
In conclusion, duration of neonatal hypoxia appears an important determinant of alterations in cardiopulmonary function that persist further into life. These changes encompass both the pulmonary vasculature, and the response of the heart to hypoxia and exercise. Abstract figure legend Exposure of Neonatal Swine to hypoxia for up to four weeks resulted in an increase in pulmonary vascular resistance (PVR) and right ventricular hypertrophy that persisted after recovery in normoxia. Exercise experiments revealed an increased dependency on nitric oxide (NO) to maintain a PVR low, as well as a reduced stroke volume (SV) during ...
Source: The Journal of Physiology - July 21, 2022 Category: Physiology Authors: Jarno J Steenhorst Alexander Hirsch Annemarie Verzijl Piotr Wielopolski Daphne de Wijs-Meijler Dirk J Duncker Irwin K M Reiss Daphne Merkus Source Type: research

Selective aortic arch perfusion for the reversal of haemorrhage-induced traumatic cardiac arrest in a swine model of non-compressible torso haemorrhage
Conclusion In this swine model of haemorrhage-induced traumatic cardiac arrest with NCTH, SAAP infers a short-term survival advantage over both conventional therapy (CPR), and over evolving therapy (REBOA). Of note, SAAP induced return of spontaneous circulation from cardiac electrical asystole. Figure 1 Figure 2
Source: Emergency Medicine Journal - November 17, 2016 Category: Emergency Medicine Authors: Barnard, E., Smith, J., Manning, J., Rall, J., Cox, J., Bebarta, V., Ross, J. Tags: Bradyarrhythmias and heart block, Drugs: cardiovascular system, Hypertension Rod Little Award Presentations Source Type: research

A descriptive paradigm of escalating endovascular intervention for the management of traumatic cardiac arrest in a swine model of non-compressible torso haemorrhage
Conclusion A step-wise approach of more complex endovascular intervention in haemorrhage-induced traumatic cardiac arrest may be an effective clinical paradigm – in this swine model all animals had short-term survival following escalating intervention: REBOA, followed by SAAP, followed SAAP-ECLS as required. Figure 1 Figure 2
Source: Emergency Medicine Journal - November 17, 2016 Category: Emergency Medicine Authors: Barnard, E., Smith, J., Manning, J., Rall, J., Cox, J., Bebarta, V., Ross, J. Tags: Bradyarrhythmias and heart block, Drugs: cardiovascular system, Hypertension Rod Little Award Presentations Source Type: research

Structural and functional changes of the pulmonary vasculature after hypoxia exposure in the neonatal period - a new swine model of pulmonary vascular disease.
In conclusion, we developed a neonatal swine model that allows examination of the long-term sequelae of damage to the developing neonatal lung, the course of the disease, and the effect of therapy on long-term outcome. PMID: 29127236 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 10, 2017 Category: Physiology Authors: de Wijs-Meijler DPM, van Duin RWB, Duncker DJ, Scherrer U, Sartori C, Reiss IKM, Merkus D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Pulmonary microvascular remodeling in chronic thrombo-embolic pulmonary hypertension.
CONCLUSIONS: Pulmonary microvascular remodeling with a reduced activity of PDE5 and Rho-kinase may contribute to the lack of therapeutic efficacy of PDE5-inhibitors and Rho-kinase inhibitors in CTEPH. PMID: 30260284 [PubMed - as supplied by publisher]
Source: Am J Physiol Lung Ce... - September 27, 2018 Category: Respiratory Medicine Authors: Stam K, van Duin RWB, Uitterdijk A, Krabbendam-Peters I, Sorop O, Danser AHJ, Duncker DJ, Merkus D Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Right Ventricular Oxygen Delivery as a Determinant of Right Ventricular Functional Reserve during Exercise in Juvenile Swine with Chronic Pulmonary Hypertension.
CONCLUSION: The inability to sufficiently increase RV-O2supply to meet the increased O2demand during exercise is principally due to the reduced RV-perfusion relative to healthy control values and likely contributes to impaired RV-contractile function and thereby to the limited exercise capacity that is commonly observed in patients with PH. PMID: 31398061 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 8, 2019 Category: Physiology Authors: Cai Z, van Duin RWB, Stam K, Uitterdijk A, van der Velden J, Vonk-Noordegraaf A, Duncker DJ, Merkus D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Study of Profile of Swine Flu Cases Admitted in Tertiary Care Hospital: Lessons Learned!
Introduction Swine flu is caused by a novel strain of H1N1 influenza A virus that evolved by genetic assortment. The global pandemic affected India in May 2009. Sporadic cases continue to occur and cause significant morbidity and mortality. Aim To study the clinical profile, laboratory parameters, and outcome of the confirmed cases of swine flu. Methods This was a retrospective study involving confirmed swine flu cases admitted with category B2 and C symptoms from February to September 2019 in Tata Main Hospital. Their case records were analyzed for demographic characteristics, clinical features, treatmen...
Source: Infectious Diseases in Clinical Practice - May 1, 2021 Category: Infectious Diseases Tags: Original Articles Source Type: research